Role: Principal Investigator Funding dates: 7/1/2022 - 6/30/2027

Award: R01 (HL164416)

Title: Targeting Immune-Responsive Gene 1 (Irg1) and Itaconate for Cardioprotection of the Donor Hearts for Transplantation.

Overview: This project uses metabolic reprogramming of donor hearts to improve cardiac performance and ischemic tolerance.

Role: Principal Investigator Funding dates: 7/1/2021 - 6/30/2022

Award: Gardner Surgical Investigator

Title: Optimization of donor heart preservation through mineralocorticoid receptor inhibition

Overview: This project uses mineralocorticoid inhibition to reduce primary graft dysfunction in donor hearts.

Role: Co-Investigator Funding dates: 7/1/2022 - 6/30/2026

Award: R01 (HL160730)

Title: Regulation of Cardiac Collagen Content by SLIT3

Overview: This project examines the role of SLIT3 in heart failure with preserved ejection fraction

Role: Principal Investigator Funding dates: 7/1/2019 - 6/30/2020

Award: Investigation of mechanisms of disease Identified through the UDN using model organisms

Title: Elucidation of the Mechanism of Disease in a TAX1BP3 gene variant associated with human Arrhythmogenic Right Ventricular Cardiomyopathy

Overview: This project determined the role of TAX1BP3 in the mechanism of familial arrhythmogenic cardiomyopathy.

Role: Principal Investigator Funding dates: 7/1/2018 - 6/30/2019

Award: TSF-STSA Research Grant

Title: Improving Donor Heart Function Following Ischemia-Reperfusion Injury by Innate Immune Inhibition Using Valproic Acid

Overview: This project determined the role of Valproic Acid in improving donor heart function in large animal (pig) hearts.

Role: Principal Investigator Funding dates: 7/1/2017 - 6/30/2019

Award: 3rd John Alexander Research Scholar

Title: Inflammatory Mediators of Aortic Dissection and Rupture in Marfan Syndrome

Overview: This project determined the role of innate immunity in Marfan Syndrome associated thoracic aortic aneurysm progression.

Role: Principal Investigator Funding dates: 7/1/2017 - 6/30/2019

Award: Clinical trial - EXPAND

Title: International Trial to Evaluate the Safety and Effectiveness of the Portable Organ Care System (OCS) Heart for Recruiting, Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation (EXPAND Heart Trial)

Overview: This project determined the efficacy of normothermic ex-vivo perfusion in expanding the donor pool for heart transplantation.